Muscle Protein Synthesis
There was a recent thread where this was discussed. I was involved and this topic is very complicated but also very interesting. I test positive for being a fitness nerd I would say. I’ll gladly pee in any cup, but I wanted to explain in a more detailed manner for those looking to get in shape and build muscle or any goals related to this. Understanding this process will help you avoid wasting time and make as much gains as possible.
There are two processes related to muscle growth or deterioration that are happening concurrently all the time around the clock. One is muscle building and growth called Muscle Protein Synthesis (mps) and the other, the breakdown of muscle tissue, Muscle Protein Breakdown (mpb). Both are essential for normal healthy physical function.
In a normal healthy person who is relatively maintaining weight, the rate of mps and mpb is balanced and the person neither gains nor loses muscle. This process is independent of calorie intake. The rate of mpb is almost always the same and very little can be done to effect this. It’s a necessary function as it steadily breaks down muscle so that fresh new muscle is always available. This is when mps comes in to provide the new muscle. As mentioned, this happens daily. A constant recycling of the muscle.
The rate of mpb only slows down ever so slightly after a meal where insulin is released. It only slows a little. For mps, however the rate can be manipulated more easily and dramatically.
The main thing that triggers mps is exercise or resistance training specifically. Protein intake will increase it as well. So what happens is through these activities you’re increasing your daily mps and because we know mpb doesn’t change much, now you’ve done a miraculous thing. You’re rate of mps out weighs your rate of mpb and now you are in positive balance. Now your body is building more muscle then it’s breaking down. This is the key to muscle growth through strength training. It’s not what the main theory that goes around where it’s said weight training tears the muscle and then it grows back stronger. It will tear the muscle, this is true, if done close to or to failure but this isn’t the goal. The goal is to stimulate mps and with proper protein intake to provide the building blocks and you put yourself in positive balance and build muscle.
If you were to decrease mps and the rate of mpb surpassed mps then you’d be in negative balance and would lose muscle mass. Certain things can inhibit mps, like prolonged starvation or certain hormones like cortisol. Then you’d lose muscle mass. Which is why you want to avoid stress of any kind while attempting to build your body up.
The average person is in neutral balance. And neither gains nor loses. To illustrate more clearly how this works, let me give an example.
Say a person wakes up and has a protein rich breakfast. The protein will spike mps while the insulin (insulin is anabolic, meaning promotes growth) which is released in any meal regardless of macro nutrients, meaning you could have carbs, fat or protein and insulin is released, will suppress mpb. Sufficient insulin levels that need to be released to bring the maximum suppression of mpb is very small. A single cookie would do the trick. So a protein rich meal will put a person in positive balance for a few hours. Mps is increased and insulin decreases mpb so positive balance is achieved. As hormone levels balance out after the meal mps drops and mpb raises back up and now the person is in negative balance. This process repeats through the day with each meal and will balance out to neutral balance to the average person maintaining their weight.
So if all the same factors are in place, but however the person is strength training and increasing protein intake, then those added activities create an overall positive balance in the day and you are building muscle. This process, as said, is independent of calorie intake and a calorie surplus isn’t needed to build muscle. Adequate protein intake is the factor along with training. The only time calories play a factor is if one is at a deficit for too long. Then mps will drop as the body thinks it’s starving. What is too long? Too long can be a large deficit of more than three days on average. Then mps rates will lower. So trying to build muscle and lose fat, it’s wise to keep the deficit small and cycle your deficit days. Three in a deficit, then aim for maintenance level and then back to the deficit. This should prevent a drop in mps for most individuals. This is to be cautious. However, strength training alone should be enough for preventing a slower rate of mps, provided the calorie deficit isn’t too dramatic and you have a high protein intake. Keep the deficit only a few hundred calories, but I will say, for best muscle building results always aim for as close to maintenance level of calories as possible.
Timing protein intake is a whole other can of worms but for the average gainer it isn’t something to worry about. Just get your daily intake needs met. Shoot for 1g/lb of body weight. More wont hurt, but less has been shown to be statistically inadequate. The timing of protein intake does give benefits but only 10-20% better results and isn’t significant to the average gainer. Only those wanting to maximize gains and are willing to put extra effort need worry about it.
But I can discuss that more if it’s an interest.
The process is very interesting to me. I would enjoy talking about any details to any one interested. Specifically I can explain the science behind training in a general sense if there’s interest. There’s so many wild variables to training. You have to think of goals, the individual persons genetics, etc. but there are observable truths that hold across the board that can be applied to any training situation to maximize success. And it’s very interesting.
There was a recent thread where this was discussed. I was involved and this topic is very complicated but also very interesting. I test positive for being a fitness nerd I would say. I’ll gladly pee in any cup, but I wanted to explain in a more detailed manner for those looking to get in shape and build muscle or any goals related to this. Understanding this process will help you avoid wasting time and make as much gains as possible.
There are two processes related to muscle growth or deterioration that are happening concurrently all the time around the clock. One is muscle building and growth called Muscle Protein Synthesis (mps) and the other, the breakdown of muscle tissue, Muscle Protein Breakdown (mpb). Both are essential for normal healthy physical function.
In a normal healthy person who is relatively maintaining weight, the rate of mps and mpb is balanced and the person neither gains nor loses muscle. This process is independent of calorie intake. The rate of mpb is almost always the same and very little can be done to effect this. It’s a necessary function as it steadily breaks down muscle so that fresh new muscle is always available. This is when mps comes in to provide the new muscle. As mentioned, this happens daily. A constant recycling of the muscle.
The rate of mpb only slows down ever so slightly after a meal where insulin is released. It only slows a little. For mps, however the rate can be manipulated more easily and dramatically.
The main thing that triggers mps is exercise or resistance training specifically. Protein intake will increase it as well. So what happens is through these activities you’re increasing your daily mps and because we know mpb doesn’t change much, now you’ve done a miraculous thing. You’re rate of mps out weighs your rate of mpb and now you are in positive balance. Now your body is building more muscle then it’s breaking down. This is the key to muscle growth through strength training. It’s not what the main theory that goes around where it’s said weight training tears the muscle and then it grows back stronger. It will tear the muscle, this is true, if done close to or to failure but this isn’t the goal. The goal is to stimulate mps and with proper protein intake to provide the building blocks and you put yourself in positive balance and build muscle.
If you were to decrease mps and the rate of mpb surpassed mps then you’d be in negative balance and would lose muscle mass. Certain things can inhibit mps, like prolonged starvation or certain hormones like cortisol. Then you’d lose muscle mass. Which is why you want to avoid stress of any kind while attempting to build your body up.
The average person is in neutral balance. And neither gains nor loses. To illustrate more clearly how this works, let me give an example.
Say a person wakes up and has a protein rich breakfast. The protein will spike mps while the insulin (insulin is anabolic, meaning promotes growth) which is released in any meal regardless of macro nutrients, meaning you could have carbs, fat or protein and insulin is released, will suppress mpb. Sufficient insulin levels that need to be released to bring the maximum suppression of mpb is very small. A single cookie would do the trick. So a protein rich meal will put a person in positive balance for a few hours. Mps is increased and insulin decreases mpb so positive balance is achieved. As hormone levels balance out after the meal mps drops and mpb raises back up and now the person is in negative balance. This process repeats through the day with each meal and will balance out to neutral balance to the average person maintaining their weight.
So if all the same factors are in place, but however the person is strength training and increasing protein intake, then those added activities create an overall positive balance in the day and you are building muscle. This process, as said, is independent of calorie intake and a calorie surplus isn’t needed to build muscle. Adequate protein intake is the factor along with training. The only time calories play a factor is if one is at a deficit for too long. Then mps will drop as the body thinks it’s starving. What is too long? Too long can be a large deficit of more than three days on average. Then mps rates will lower. So trying to build muscle and lose fat, it’s wise to keep the deficit small and cycle your deficit days. Three in a deficit, then aim for maintenance level and then back to the deficit. This should prevent a drop in mps for most individuals. This is to be cautious. However, strength training alone should be enough for preventing a slower rate of mps, provided the calorie deficit isn’t too dramatic and you have a high protein intake. Keep the deficit only a few hundred calories, but I will say, for best muscle building results always aim for as close to maintenance level of calories as possible.
Timing protein intake is a whole other can of worms but for the average gainer it isn’t something to worry about. Just get your daily intake needs met. Shoot for 1g/lb of body weight. More wont hurt, but less has been shown to be statistically inadequate. The timing of protein intake does give benefits but only 10-20% better results and isn’t significant to the average gainer. Only those wanting to maximize gains and are willing to put extra effort need worry about it.
But I can discuss that more if it’s an interest.
The process is very interesting to me. I would enjoy talking about any details to any one interested. Specifically I can explain the science behind training in a general sense if there’s interest. There’s so many wild variables to training. You have to think of goals, the individual persons genetics, etc. but there are observable truths that hold across the board that can be applied to any training situation to maximize success. And it’s very interesting.