The North Node indicates a destined path we take in life, also of fate. It also indicates something we should strive for and work for to improve things in our lives.
The South Node is of fate, past life karma for better or for worse, and special abilites and gifts.
Both opposite and balance each other out. Each one has what the other one lacks and they each have the ability to tone down so to speak.
When sublimated through Yoga, power meditation or through positive actions of their respective qualities, the negative traits of these are lessened. Still, some work needs to be done such as removing negative karma from ones soul through Freeing the Soul working, or other workings that removes negativity and so on.
Negative degrees can bring drastic changes of a negative nature, but keeping your energies high through Yoga for an example or other types of Power Meditation is paramount in dealing with negativity, as much will be deflected. Always keep your energies high, and always clean your chakras and aura, along with Aura of Protection!