Sounds like a great way to express yourself and connect with the Gods. They always appreciate what you make. They've always smiled on me for crafting and creativity. It is one of my favorite ways to emulate Them.
My collection of Runes has changed much over the years and I did a similar thing you plan to do with your deer antler.
I made my Othaal Rune out of a piece of petrified wood I found in a creek and it feels incredible to me.
Your runes will feel right to you if you listen and meditate with them as you create them.
I also have some antler but haven't made runes with it. You should try it!