Please no theoritical answers, only practical and testimonial
My practical, and testimonial answer here should be sufficient I feel:
My beloved wife has had to take small dosages of anti-psychotics on and off for some years for some recurring issues that are being addressed over time with a healing working.
These are unfortunately very deep seated mental problems so some anti-psychotics are necessary, as she sometimes experiences very harmful mental breakdowns, and can't control it.
I have sometimes, often dealt with the blunt of this as well and have been the only person able to help and assist, reign her in when these occur. Unfortunately, some people in this world are really doing their best and they are slow at improving and getting better, even with the methods and knowledge we have here.
If one is on small dosages, then this does not affect the psychic centers or higher faculties to a strong extent, and this is still fully possible and doesn't hinder astral communication.
At higher dosages. This moderately and or completely hinders and inhibits the psychic senses.
Lastly, you want to be using these with the plan in mind to eventually be healed and only use them until you are able to wean off of them. You must combine this with strong healing workings and deep spiritual work.
The easiest way is to be on small effective dosages, which do not hinder the senses but also are able to help control serious problematic symptoms that can be catastrophic for one's life and loved ones.