The outer planets (Uranus, Neptune, Pluto) have a more personal influence when their corresponding sign is on the Ascendant and therefore a main Ruler of the Natal Chart.
Even if they are in the first house, they form many planetary aspects with other planets (especially a Chart Ruler).
The outer Planets if retrograde are much more internal and their energies manifest differently in the soul of the owner of the natal chart.
In these cases the sign in which the transcendental outer planet is found represents an energy trait that must be read by the Astrologer, the traits of the sign will be reinforced in the personality, it is very useful to merge the rulerships of the planets and signs in question.
The strength of the planet itself in the sign in which it is found must also be taken into consideration, for example Neptune in Capricorn can reduce the imagination that Neptune provides if there are factors in the natal chart that support this.
In the case of Uranus retrograde in Domicile in Aquarius and if there are other factors in the theme described above, the person in the birth chart can be very rebellious and original, a lover of freedom and technology, an introvert with variable ability in science and technology, Uranus retrograde in Aquarius in the first house or as ruler reveals a marked scientific and technological ability, in extreme cases there can also be neurodivergence and consequently even exceptional mental gifts, unusual depending on the rest of the theme and the manifestation of the energies of the planets in the soul.